论文摘要
目的:研究大鼠股骨骨折合并脑外伤时血清leptin水平及骨痂组织中Leptin的表达,探讨Leptin与骨折合并脑外伤时骨折愈合加快的关系。方法:将64只SD大鼠随机分为4组:对照组、脑外伤组、骨折组和骨折合并脑外伤组各16只.建立大鼠中度脑损伤和骨折模型,分别于1、2、4、8、12周取血清,放射免疫法测血清中Leptin水平,骨折标本摄X线片,骨痂组织作HE染色及免疫组化。结果:第2,4,8周与对照组相比骨折并脑外伤组、脑外伤组、骨折组大鼠血清Leptin浓度均有显著性增高(P＜0.05);第4周时骨折并脑外伤组大鼠血清Leptin升高水平较其它两组明显(P＜0.05);从第8周开始,手术3组大鼠血清Leptin浓度都有所下降,但骨折并脑外伤组Leptin浓度仍明显高于其它两组(P＜0.05);第12周各组之间无统计学差异(P＞0.05)。脑外伤合并骨折组形成骨痂体积在X线片上高于单纯股骨骨折组,差异有显著性(P＜0.05)。骨折合并脑外伤组中骨痂组织Leptin免疫组化染色平均阳性细胞数比骨折组有显著性增加(p＜0.05)。结论:伴有脑外伤的骨折愈合过程中,在一定时间内血清Leptin水平升高,骨折愈合加快,提示Leptin是脑外伤后骨折愈合加速的因素之一。
论文目录
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