论文摘要
子宫内膜异位症（endometriosis,EMs）是育龄期妇女的常见病,发病率可高达15%。EMs虽为良性病变,但具有类似恶性肿瘤种植生长和远处转移的特征,临床上主要表现为疼痛和不孕,EMs发病的确切病因尚不清楚。腹腔镜检查仍是目前诊断内异症的最佳方法。EMs既没有最佳治疗方案,也不能达到完全治愈的效果。目前,EMs的治疗目的主要有以下三点:1)减轻疼痛;2)帮助受孕;3)延缓复发。尽管药物治疗能缓解疼痛,但由此产生的卵巢功能抑制及药物副作用等问题降低了患者的生活质量。大量研究表明,免疫系统的变化,免疫成分的失衡,以及腹腔中的巨噬细胞、NK细胞及细胞毒性T细胞作用的被抑制,各种免疫细胞及其分泌的细胞因子的功能紊乱均可能与EMs的发病机制有关。越来越多的文献报道,TNF-α这种前炎症因子,作为激活的单核细胞、巨噬细胞、淋巴细胞的毒性产物,在EMs以及EMs相关性不孕患者腹腔液申明显升高,甚至有文献认为TNF-α的水平可作为EMs活动程度和分期的标志。这说明TNF-α可能与EMs以及EMs相关性不孕的发生发展有关,在EMs以及EMs相关性不孕的病理生理过程中起了重要的作用。故TNF-α拮抗剂,
论文目录
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标签：子宫内膜异位症论文; 基质细胞论文; 腺上皮细胞论文; 体外培养论文; 肿瘤坏死因子论文; 可溶性肿瘤坏死因受体论文; 免疫组织化学论文;