本文主要研究内容
作者吴兰（2019）在《清瘟解毒口服液的制备及工艺优化》一文中研究指出：近年来在兽药领域,清瘟解毒口服液是较受欢迎的清热解毒药物,该口服液为纯中药制剂,其功效为清热解毒,主治外感发热。其传统生产工艺药材有效成分提取率偏低、除杂浓缩环节损失高、能耗高。同时,在国家质量标准中清瘟解毒口服液为定性鉴别,缺乏主要药效成分的定量检测,影响了产品质量稳定性的控制,可能导致产品临床疗效有较大差异。针对上述问题,本论文建立了清瘟解毒口服液重要成份——连翘苷的高效液相色谱检测方法,以此来对口服液中的连翘苷含量进行定量分析。通过研究制备工艺中的关键环节——粉碎提取和过滤除杂工艺,提高该药品活性成分收率,提升清瘟解毒口服液的品质,降低资源损耗,节约生产成本。本论文的研究结果如下:(1)建立了连翘苷高效液相色谱检测方法通过系统的实验,建立了连翘苷的高效液相色谱法,连翘苷的高效液相色谱条件为:采用kromasrlC18(250mm*4.6mm*5μm)色谱柱,并以乙腈和0.2%(质量分数)的磷酸溶液(22:78)为流动相。检测波长为274nm,流速为1.OmL/min,柱温为40℃,进样量10μL。结果表明,该实验的准确性高、稳定性强、重复性高,可以作为连翘苷的定量检测方法。(2)改进了清瘟解毒口服液粉碎提取的工艺参数通过将清瘟解毒口服液的原材料进行粉碎预处理研究后,发现不同的粉碎程度,检测到的连翘苷的含量也不同,根据单因素实验,结果表明,清瘟解毒口服液的最佳粉粹提取工艺参数为:药材粉碎过24目筛时,提取时间为50分钟,提取温度控制在90℃,加水景达到药材的八倍,在上述工艺参数条件下所获得的活性成分提取量最高。(3)改进了消瘟解毒口服液过滤除杂的工艺参数在粉碎提取之后,使用陶瓷膜对药物进行过滤除杂。研究数据表明,清瘟解毒口服液中最佳陶瓷膜过滤工艺参数为:陶瓷膜的孔径为0.6μm,药液温度为25℃,压力设置为0.20MPa,根据此工艺参数制得的清瘟解毒口服液最终得到的连翘苷含量高,且药液澄清度好。(4)清瘟解毒口服液新工艺的中试生产按照实验室优化后的工艺参数,中试生产清瘟解毒口服液,成品的检验结果表明,药液活性成分含量能够达到峰值,药液活性成分提取率达到42.8%。通过长期试验数据得出,本次的生产药液在研究的六个月中,连翘苷含量、药液性状、理化性质等各项指标都符合规定。新工艺生产的清瘟解毒口服液在经过生产中试放大后,可以保证产品的稳定性,证实了优化后的工艺具有可行性。
Abstract
jin nian lai zai shou yao ling yu ,qing wen jie du kou fu ye shi jiao shou huan ying de qing re jie du yao wu ,gai kou fu ye wei chun zhong yao zhi ji ,ji gong xiao wei qing re jie du ,zhu zhi wai gan fa re 。ji chuan tong sheng chan gong yi yao cai you xiao cheng fen di qu lv pian di 、chu za nong su huan jie sun shi gao 、neng hao gao 。tong shi ,zai guo jia zhi liang biao zhun zhong qing wen jie du kou fu ye wei ding xing jian bie ,que fa zhu yao yao xiao cheng fen de ding liang jian ce ,ying xiang le chan pin zhi liang wen ding xing de kong zhi ,ke neng dao zhi chan pin lin chuang liao xiao you jiao da cha yi 。zhen dui shang shu wen ti ,ben lun wen jian li le qing wen jie du kou fu ye chong yao cheng fen ——lian qiao gan de gao xiao ye xiang se pu jian ce fang fa ,yi ci lai dui kou fu ye zhong de lian qiao gan han liang jin hang ding liang fen xi 。tong guo yan jiu zhi bei gong yi zhong de guan jian huan jie ——fen sui di qu he guo lv chu za gong yi ,di gao gai yao pin huo xing cheng fen shou lv ,di sheng qing wen jie du kou fu ye de pin zhi ,jiang di zi yuan sun hao ,jie yao sheng chan cheng ben 。ben lun wen de yan jiu jie guo ru xia :(1)jian li le lian qiao gan gao xiao ye xiang se pu jian ce fang fa tong guo ji tong de shi yan ,jian li le lian qiao gan de gao xiao ye xiang se pu fa ,lian qiao gan de gao xiao ye xiang se pu tiao jian wei :cai yong kromasrlC18(250mm*4.6mm*5μm)se pu zhu ,bing yi yi jing he 0.2%(zhi liang fen shu )de lin suan rong ye (22:78)wei liu dong xiang 。jian ce bo chang wei 274nm,liu su wei 1.OmL/min,zhu wen wei 40℃,jin yang liang 10μL。jie guo biao ming ,gai shi yan de zhun que xing gao 、wen ding xing jiang 、chong fu xing gao ,ke yi zuo wei lian qiao gan de ding liang jian ce fang fa 。(2)gai jin le qing wen jie du kou fu ye fen sui di qu de gong yi can shu tong guo jiang qing wen jie du kou fu ye de yuan cai liao jin hang fen sui yu chu li yan jiu hou ,fa xian bu tong de fen sui cheng du ,jian ce dao de lian qiao gan de han liang ye bu tong ,gen ju chan yin su shi yan ,jie guo biao ming ,qing wen jie du kou fu ye de zui jia fen cui di qu gong yi can shu wei :yao cai fen sui guo 24mu shai shi ,di qu shi jian wei 50fen zhong ,di qu wen du kong zhi zai 90℃,jia shui jing da dao yao cai de ba bei ,zai shang shu gong yi can shu tiao jian xia suo huo de de huo xing cheng fen di qu liang zui gao 。(3)gai jin le xiao wen jie du kou fu ye guo lv chu za de gong yi can shu zai fen sui di qu zhi hou ,shi yong tao ci mo dui yao wu jin hang guo lv chu za 。yan jiu shu ju biao ming ,qing wen jie du kou fu ye zhong zui jia tao ci mo guo lv gong yi can shu wei :tao ci mo de kong jing wei 0.6μm,yao ye wen du wei 25℃,ya li she zhi wei 0.20MPa,gen ju ci gong yi can shu zhi de de qing wen jie du kou fu ye zui zhong de dao de lian qiao gan han liang gao ,ju yao ye cheng qing du hao 。(4)qing wen jie du kou fu ye xin gong yi de zhong shi sheng chan an zhao shi yan shi you hua hou de gong yi can shu ,zhong shi sheng chan qing wen jie du kou fu ye ,cheng pin de jian yan jie guo biao ming ,yao ye huo xing cheng fen han liang neng gou da dao feng zhi ,yao ye huo xing cheng fen di qu lv da dao 42.8%。tong guo chang ji shi yan shu ju de chu ,ben ci de sheng chan yao ye zai yan jiu de liu ge yue zhong ,lian qiao gan han liang 、yao ye xing zhuang 、li hua xing zhi deng ge xiang zhi biao dou fu ge gui ding 。xin gong yi sheng chan de qing wen jie du kou fu ye zai jing guo sheng chan zhong shi fang da hou ,ke yi bao zheng chan pin de wen ding xing ,zheng shi le you hua hou de gong yi ju you ke hang xing 。
论文参考文献
论文详细介绍
论文作者分别是来自山西大学的吴兰，发表于刊物山西大学2019-11-12论文，是一篇关于口服液论文,连翘苷论文,粉碎论文,除杂论文,山西大学2019-11-12论文的文章。本文可供学术参考使用，各位学者可以免费参考阅读下载，文章观点不代表本站观点，资料来自山西大学2019-11-12论文网站，若本站收录的文献无意侵犯了您的著作版权，请联系我们删除。
标签：口服液论文; 连翘苷论文; 粉碎论文; 除杂论文; 山西大学2019-11-12论文;