论文摘要
转化生长因子β（transforming growth factors-β, TGF-β）是一类对各种细胞具有多种功能的多肽类细胞因子,除了在调节细胞增殖、分化、凋亡,细胞外基质形成、细胞移动、粘附,胚胎发育、组织器官形态发生等方面发挥重要作用,还可能与肿瘤的发生、发展、转移等密切相关。近来对TGF-β诱导的受体后信号转导途径机制的研究多集中于其早期瞬时信号分子,如:Smads、Src激酶家族成员和Rac-Ras GTP酶家族的成员,其中以Smads通路的研究最深入。TGF-β通过与细胞膜受体结合,将信号传递到下游分子Smads,磷酸化的Smads分子入核,调控相关基因的表达,从而发挥其生物学效应。丝裂原活化蛋白激酶（mitogen-activated protein kinase, MAPK）是联系细胞膜受体与细胞内重要调节靶目标的进化保守的酶类,这一系统把细胞外刺激传递到核,介导细胞反应,其中ERK是受外界刺激时决定细胞命运的关键性因素,在一系列反应如生长因子和有丝分裂等刺激中被激活,同时其持续活化最终促进细胞增殖和恶性转化。有很多研究证实了上皮性肿瘤中,TGF-β可能调节多种MAPK通路,激活的模式非常多样,且与细胞类型相关。但软组织肿瘤中TGF-β对Smad途径和MAPK途径的相互调节罕见报道。
论文目录
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