论文摘要
目的了解系统性红斑狼疮（systemic lupus erythematosus, SLE）合并心脏损害患者的临床特征,并探讨SLE心脏损害的危险因素及其他脏器损害情况,为SLE合并心脏损害的临床诊疗提供依据。方法收集2005年1月至2010年12月宁夏医科大学总医院确诊SLE合并心脏损害的住院患者的临床资料,以同期住院的无心脏损害的SLE患者作为对照,分析SLE心脏损害患者的临床特征;比较两组间临床和实验室检查的差异,通过Logistic回归分析初步探讨SLE心脏损害的危险因素;并通过比较两组间SLICC损伤指数（SDI）积分进一步了解其他脏器损害情况。结果在114例SLE合并心脏损害患者中,超声心动图检查异常者107例,其中心包积液45例（45/114）,占39.47%,瓣膜反流41例（41/114）,占35.96%,左室舒张功能减低24例（24/114）,占21.01%,心脏扩大20例（20/114）,占17.5%,肺动脉压升高者11例（11/114）,占9.65%。心电图检查异常者47例,其中窦性心动过速27例（27/114）,占23.7%,ST-T异常22例（22/114）,占19.3%,房室传导阻滞5例,窦性心动过缓3例,频发室性期前收缩、频发房性期前收缩各1例。单因素分析显示,与系统性红斑狼疮患者心脏损害的相关因素包括:病程、发热、浆膜炎、神经精神狼疮、贫血、肾脏损害、SLEDAI≥10、抗Sm抗体、抗ds-DNA结合率、ANCA、补体C3、甘油三酯、高密度脂蛋白。经Logistic回归分析显示,系统性红斑狼疮患者合并心脏损害的危险因素包括:贫血、低补体C3、高密度脂蛋白降低。结论1.合并贫血、低补体C3、高密度脂蛋白降低的SLE患者易出现心脏损害。2.合并心脏损害的SLE患者其他器官损害程度也较高,需及时全面的了解SLE脏器损害情况。
论文目录
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