论文摘要
目的：探讨淋巴母细胞淋巴瘤（lymphoblastic lymphoma,LBL）的临床、免疫遗传及治疗特点。方法：对我院2011年新确诊的4例淋巴母细胞淋巴瘤临床资料的回顾性分析的基础上,复习近年文献并讨论。结果：4例LBL中3例为T-LBL,1例为B-LBL,3例T-LBL中,2例累及纵膈淋巴结,1例B-LBL累及皮肤。3例T-LBL中,均表达CD3,而1例B-LBL CD20和CD79a均阳性,另外4例LBL患者均表达CD99和TdT。通过Hyper-CVAD方案治疗后,1例为CR,另外3例分别处于PR、SD、PD,其中1例年轻患者化疗获得CR后行自体干细胞移植,目前仍处于CR。结论：不同的LBL亚型有不同的临床表现,确诊分型主要通过免疫表型特点,Hyper-CVAD方案已成为一线治疗方案,高危患者可考虑高剂量化疗联合自体或异基因干细胞移植解救。
论文目录
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标签：淋巴母细胞淋巴瘤论文; 临床特点论文; 免疫表型论文; 细胞遗传论文; 治疗论文;