论文摘要
大量流行病学研究显示，中、重度牙周炎与心血管疾病（cardiovascular disease，CVD），尤其是冠心病（coronary heart disease，CHD）高度相关，可能是CHD的危险因素。但牙周炎与CVD流行病学相关性的生物学基础尚不清楚。 凝血因子纤维蛋白原（fibrinogen，Fg），是急性期蛋白之一，在急性反应期水平可升高2～10倍；且Fg水平的升高与Fgβ-455（G／A）基因多态性相关。研究表明，血浆Fg水平升高与CHD的发生密切相关，是CHD事件重要的独立危险因素。牙周炎可能通过其炎症反应产生的促炎细胞因子造成Fg合成增加、使循环Fg水平升高，从而影响CHD的发生发展。然而，Fg可否作为联系牙周炎与CHD的纽带，目前尚无定论。中国人牙周炎与CHD的关系也未见报道。 研究发现，与CHD相关的主要是中、重度牙周炎，然而，牙周炎易感性及严重程度具有明显的、无法以细菌差异来解释的个体差异。目前认为，遗传因素在决定宿主牙周炎易感性上起着重要作用。并且，牙周炎与CHD作为多因素疾病，很难以单一基因的变异解释其发生。因此，对白细胞介素、肿瘤坏死因子等炎症性疾病候选基因之外的遗传因素，如Fg等，进行研究，
论文目录
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标签：牙周炎论文; 冠心病论文; 相关机制论文; 纤维蛋白原论文; 基因多态性论文; 牙龈卟啉单胞菌论文; 中性多形核白细胞论文; 炎症反应论文;