论文摘要
目的 研究病毒性肝炎患者血清瘦素(leptin)水平的改变,旨在为了解leptin在病毒性肝炎的发病机制中所起的作用,以及病毒性肝炎对血清leptin水平的影响,从而为病毒性肝炎的发病机制以及进一步的辅助诊断提供新的思路。 方法 选择诊断明确的病毒性肝炎患者167例(男85例,其中乙肝44例,丙肝41例,女82例,其中乙肝42例,丙肝40例),脂肪肝患者87例(男42例,女45例),正常对照组80例(男40例,女40例),检测其血清leptin水平及各种生化指标,比较各组之间的leptin水平以及leptin与各生化指标之间的相关性。 结果 病毒性肝炎(HBV、HCV)患者血清leptin水平较脂肪肝患者及正常对照组均高(P<0.05):女性脂肪肝患者血清leptin水平较正常对照组高(P<0.05);而男性脂肪肝患者血清leptin水平与对照组比较无显著差异(P=0.7811);乙型肝炎和丙型肝炎患者血清leptin水平较正常对照组均明显增高(P<0.05);乙型肝炎“小三阳”和“大三阳”患者血清leptin水平无显著差异(P>0.05);血清leptin水平与谷丙转氨酶(ALT)、谷草转氨酶(AST)呈显著性正相关(P<0.05);而与血糖(Glu)、总胆固醇(TC)无明显相关性(P>0.05)。 结论 病毒性肝炎(HBV、HCV)患者血清leptin水平升高且与肝脏炎症病变严重程度有关,leptin可以作为一个判断肝脏炎症严重程度的指标。研究leptin在不同肝病中的变化和作用,对于今后的临床治疗和肝病预防具有重要的意义。
论文目录
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