论文摘要
系统性红斑狼疮(systemic lupus erythematosus,SLE)好发于生育年龄的妇女。病因尚不清楚,可能是遗传、病毒感染、某些环境和激素等因素的相互作用使自身组织细胞结构改变,或免疫活性细胞发生突变,从而失去自身耐受性,造成的机体免疫调节失常的结果。 SLE是一种可累积全身任何脏器的自身免疫性疾病,临床上有多种表现。其中在血液系统表现上较为多样化,有些患者临床表现不典型,容易造成临床上的误诊。根据临床经验,当SLE伴发血小板减少时,患者症状往往较血小板正常的SLE患者严重,且治疗上较后者困难。SLE导致血小板减少的原因是多方面的,其中自身抗体中以抗血小板抗体及抗心磷脂抗体与血小板减少关系最密切。 我们在判断SLE患者病情时,往往用系统性红斑狼疮疾病活动指数(systemic lupus erythematosus disease activity index,SLEDAI)来表示,该指数被认为是测试SLE活动性的金标准,具有较高的客观性。但是,该评分标准内容较多,共24项指标。在临床实际工作中,有一定的限制性。 随着科技进步和研究手段的改进,特别是流式细胞术(flow cytometry,FCM)被引入临床后,使对SLE的研究有了巨大的飞跃。该技术主要是通过流式细胞仪对SLE患者的淋巴细胞及其亚群以及淋巴细胞功能的分析,从而对于SLE的诊断、治疗以及疗效的观察,有了比较全面的掌握。同时FCM以其快速、敏感、准确的优点用于血小板活化状态的检测,在许多疾病诊治中都有广泛应用,但
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