Background The objective of this study is to analyze the clinical spectrum of Severe Cutaneous Adverse Drug Reactions （SCADRs）, and the causative agents at a hospital-based retrospective study for period 6 years.Methods All inpatients patients that consulting for SCADRs at Dermatology and Venereology Department of First Affiliated Hospital of Chong Qing Medical University from January, 2002 to August, 2007 were included in the study. A retrospective analysis of 41 SCADRs cases. Result were analyze with SPSS 13.0 statistical software by using Parametric test （ANOVA , LSD, t test） and nonparametric test （Pearson Chi-Square, Kruskal-Wallis, Mann-Whitney test） for hypothesis testing. Finding was considered statistically significant if the p value < 0.05.Results From 253 Cutaneous Adverse Drug Reactions （CADRs） cases, total 41 patients were diagnosed with SCADRs, which ED was the higher proportion among others, followed by SJS and TEN. The prevalence ratio of SCADRs was 11.4 per thousand per year. ED, SJS, TEN prevalence were 5.84, 2.78, 2.78 per thousand per year, respectively. SCADRs male : female ratio was 1.9: 1 （27 : 14）, the mean onset age were 43.07（SD±20.06）, the youngest age was 10 years , the oldest age was 92 years. The most common underlying disease was infection. The most common drugs that induce SCADRs were antibiotic followed by anticonvulsant.Conclusions The result of this study had many similarity to previous studies conducted in China. Infection was the common cause and antibiotic was the common induced drugs.
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